Peptide
MOTS-c
Mitochondrial ORF of the 12S rRNA Type-C
Research ChemicalEarly Human TrialsInjection (SubQ or IM)
Half-life
Unknown
Common dose
5-10mg per week
How it works
Mitochondria-derived peptide that activates AMPK pathway. Improves insulin sensitivity, metabolic flexibility, and cellular energy production.
Commonly used for
LongevityMetabolismInsulin sensitivityExercise mimetic
Potential benefits
- Exercise-mimetic effects — metabolic benefits without working out
- Dramatically improves insulin sensitivity
- Anti-aging at the mitochondrial level
- May extend lifespan based on animal data
- Unique mechanism — nothing else quite like it
Risks and downsides
- Very new — limited human data
- Expensive and hard to source reliably
- Optimal dosing protocol not established
- Animal study results may not translate directly to humans
- Injection only
Heads up: This is for educational purposes only and is not medical advice. Many compounds here are not FDA approved for human use. Please talk to a doctor before starting anything.
Risk level
Evidence
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