Best compounds
for fat loss

Ozempic, Wegovy, GLP-1 agonist

FDA-approved GLP-1 agonist producing 15–20% body weight reduction in clinical trials, results previously only seen with bariatric surgery. Reduces food noise centrally, not just appetite at mealtime. The evidence gap between this and everything else on the list is significant.

Best for: Significant fat loss, appetite control, metabolic disease

Berberine HCl, Nature's Ozempic

Activates AMPK, the same pathway as metformin. Meaningful reduction in fasting glucose and LDL cholesterol. Modest fat loss at therapeutic doses. Not 'Nature's Ozempic' as marketed, but a legitimate metabolic compound for people with insulin resistance.

Best for: Insulin resistance, metabolic syndrome, modest fat reduction

Mitochondrial ORF of the 12S rRNA Type-C

Mitochondria-derived peptide that activates AMPK and improves metabolic flexibility — the ability to efficiently burn fat as fuel. Described as an exercise mimetic at the cellular level. Far less data than berberine but a unique mechanism that no oral compound matches.

Best for: Metabolic flexibility, insulin sensitivity, advanced protocols

Anti-Obesity Drug 9604, HGH Fragment

HGH fragment (176–191) that mimics HGH's fat-burning effects without raising blood sugar or IGF-1. Failed Phase 3 trials for obesity, meaning the effect is not dramatic enough to replace real interventions. It has a clean safety profile and meaningful evidence as a protocol adjunct.

Best for: Targeted lipolysis, no glucose impact, joint health adjunct

Egrifta

The only FDA-approved GH secretagogue. Specifically demonstrated 15–18% reduction in visceral adipose tissue in Phase 3 trials — the metabolically dangerous abdominal fat. Better metabolic side effect profile than HGH. Requires daily injection.

Best for: Visceral fat specifically, off-label body recomposition

Creatine, Cr

Counterintuitive but extensively evidenced: creatine preserves lean muscle during a deficit, maintains training performance when calories are low, and keeps metabolism higher. Most people stop taking creatine on a cut. Do not stop it.

Best for: Muscle preservation, training performance during deficit

Testolone

Selectively activates androgen receptors in muscle and bone. Preserves and builds lean mass in a caloric deficit in a way that no legal supplement matches. Allows harder cuts without muscle loss. Requires PCT. Not a direct fat burner — it works by improving body composition math.

Best for: Body recomposition, muscle preservation during aggressive cut

Citrulline Malate

Improves blood flow, reduces exercise-induced ammonia accumulation, and meaningfully increases training volume and endurance when calories are low and energy is limited. More reps, better cardio sessions, more output when your body has less to work with.

Best for: Training performance and endurance during caloric deficit